The Ishaq Lab established at the University of Maine, Orono in the School of Food and Agriculture in Sept 2019, when Dr. Sue Ishaq, Principal Investigator, joined the UMaine faculty as an Assistant Professor of Animal and Veterinary Sciences. The Ishaq lab focuses on the gut microbiome of animals, and particularly in ruminants, both wild and domestic.
What we research
The majority of our work focuses on host-microbe interactions and how we can recover a stable microbial community in humans and animals which have already gotten to the point of chronic microbial community dysfunction and disease.
Microbial community structure and population dynamics are integral to community function, regardless of the specific ecosystem in which microorganisms are being studied. Dysbiosis in an animal or human host shifts the microbial communities found in or on them, and generally reduces diversity. If those disturbances to the community are repetitive there is a risk for system crash. Whether it be digesta, soil, or dust, we can use dynamic sources of microorganisms as in situ tools to cultivate a desired community.
We have three overarching research goals: 1) to better characterize microbiomes using cutting-edge technology, 2) to use this characterization to determine the relation of community structure to system functionality and homeostasis in simplified models, and 3) to develop prevention and intervention therapies which can return a perturbed microbiome back into balance in vivo.
Why we research
Human intervention changes microbial communities, and in most cases, it simplifies them – microbial diversity is lost. We can be seen in agricultural fields compared to natural environments, in urban homes compared to rural ones, and the gut of humans and animals that are considered Westernized, urban, or domesticated as compared to their counterparts who still interact with their natural surroundings on a regular basis.
But, our understanding of microbial ecosystems and how to manipulate them is still in an early state. Our goal is to increase our understanding of microbial communities involved with animals, and particularly in agricultural settings. We aim to tie this work into larger research collaborations to improve the sustainability of agriculture to promote the health of our natural environments.
The Ishaq Lab philosophy is that researchers have an obligation to share and disseminate the results of their work, and to engage both the general public and the specific groups that may benefit from those findings. As such, this site will strive to create a connection between science and, well, you! Microbiology is for sharing! And so is molecular genetics, and bioinformatics, and astrophysics…